Together, the data demonstrate that sCTLA-4 production can be consistently induced in activated T cells by the immunoregulatory cytokine TGFβ2, supporting the notion that TGFβ2, which is primarily produced by tumor cells in malignant melanoma, has the potential to induce immunosuppressive sCTLA-4 within the tumor environment. Here, TGFB2 is linked to melanoma.