In our study, we found IL-4 was highly expressed in lung fibrosis tissue of bleomycin-induced mice, and the expression of Fbxw7 was significantly decreased in bleomycin-induced mice lung issue and in BMDMs after IL-4 stimulation as shown in Figures 1, S4B and 5G. The gene discussed is FBXW7; the disease is pulmonary fibrosis.