FBXW7 and pulmonary fibrosis: Those reverse effects of Fbxw7 in AEC2 stem cells and myeloid cells in regulating lung fibrosis indicated that the pathogenesis of IPF is complicated, it involves the abnormal repair of lung tissue injury by alveolar epithelial cells, the disordered differentiation and proliferation of fibroblasts, or the hyperactivated recruitment and activation of innate immune cells.