Moreover, the expression of enhancer of zeste homolog 2 (Ezh2) is increased in IPF patients, increased Ezh2 recruitment and hypermethylated H3K27 at the promoter of fibrotic related genes have been demonstrated, such as Cox-2 (67) and Cxcl10 (68). The gene discussed is CXCL10; the disease is idiopathic pulmonary fibrosis.