FBXW7 and idiopathic pulmonary fibrosis: To investigate the role of Fbxw7 in macrophages in the pathogenesis of IPF, we generated LysM-Cre+Fbxw7fl/fl (LysM+Fbxw7fl/fl) mice (Supplementary Figure 1A) and confirmed that myeloid specific deletion of Fbxw7 does not affect the differentiation and development of myeloid cells (Supplementary Figures 1B-F).