To demonstrate the immunomodulatory effect of TGF-β-producing CD1dhiPD-L1hiCD27+ NK subset in vivo, we separated CD1dhiPD-L1hiCD27+ NK subsets and CD1dloPD-L1loCD27− NK subsets and adaptively transferred before MC903 induction of AD using a mouse model. Here, TGFB1 is linked to Alzheimer disease.