ω−3 enriched diets dramatically reduced lupus progression, mitigating glomerulonephritis and improving survival in different mouse models of SLE (258–261).ω−3 diminished anti-dsDNA antibodies (258, 261), and circulating immune complexes and their renal deposition (258).ω−3 potentiated the effects of antioxidant enzymes, enhancing the ability of renal cells to eliminate harmful free radicals (259, 261).ω−3 reduced the expression of renal pro-inflammatory cytokines including IFNγ, IL-12, TNFα (259, 261), and renal profibrotic molecules such as TGFβ and fibronectin-1 (261). The gene discussed is TNF; the disease is systemic lupus erythematosus.