Regarding the role of TLR3 signaling, although Fang et al. demonstrated that subcutaneous injection of TLR2, 3, 4, and 9 agonists could exacerbate uveitis, knockout of these genes in mice except MyD88 still resulted in the development of uveitis with similar severity (23), indicating that MyD88 but not TLR2, 3, 4 or 9 is essential for the induction of EAU. Here, TLR2 is linked to uveitis.