In humans, circulating resistin correlated with inflammatory markers and predicted coronary atherosclerosis to connect metabolic signals, inflammation and atherosclerosis (99) and was linked to obesity-induced inflammation and cardiovascular events (100), evident by correlations with proinflammatory cytokines, lipids and systolic and diastolic blood pressure in obese adolescents with metabolic syndrome (100). The gene discussed is RETN; the disease is obesity due to melanocortin 4 receptor deficiency.