AGTR2 and cardiac hypertrophy: A maternal HFD induced cardiac hypertrophy; in adult male rat offspring, it increased cardiac susceptibility to ischemic-reperfusion injury, and differentially regulated cardiac angiotensin II (AngII), AngII receptor type 1 (AGTR1) and type 2 (AGTR2) expression through various mechanisms involved in the sex-specific alterations (49).