However, the interaction found between CD8+CD57+ILT2+PD-1+ T-cell frequency and brain-PAD when predicting disability, suggests that in MS patients with a poorer brain health than expected for their age, CD8+CD57+ILT2+PD-1+ T-cell frequency may play a role in the development of physical disability. This evidence concerns the gene B3GAT1 and myeloid sarcoma.