However, sheep and ferret HF models display t-tubule loss with no change in JPH2 (Caldwell et al., 2014) and more recent investigations have reported no change in JPH2 expression in myocytes from human patients with idiopathic dilated cardiomyopathy (Hou et al., 2021) or in jph2 transcript expression in left ventricular tissue samples from patients with dilated cardiomyopathy (Frisk et al., 2021). Here, JPH2 is linked to dilated cardiomyopathy.