RYR2 and idiopathic dilated cardiomyopathy: In this special issue a study by Hou et al. also reported a trend toward smaller, more dispersed t-tubule adjacent RyR2 clusters and ~ 50% reduction in RyR2 expression in human myocytes isolated from heart samples obtained from patients with idiopathic dilated cardiomyopathy, compared to non-failing controls (Hou et al., 2021).