Furthermore, the relocated crest-localized channels exhibited a 3 to 4.5-fold enhancement in Po (Sanchez-Alonso et al., 2016) which was attributed to increased levels of constitutive channel phosphorylation due to elevated expression and activity of CaMKII in HF (Hoch et al., 1999; Kirchhefer et al., 1999; Zhang et al., 2003; Ai et al., 2005). This evidence concerns the gene CAMK2G and hydrops fetalis.