The link between reduced BIN1 expression and HF was first appreciated when Bin1 gene deletion was found to cause perinatal lethality in newborn mice who succumbed to severe ventricular cardiomyopathy within the first 24–48 h of birth (Muller et al., 2003) while cardiac specific cre-recombinase driven Bin1 knockouts were found to develop age-associated dilated cardiomyopathy (Laury-Kleintop et al., 2015). Here, BIN1 is linked to dilated cardiomyopathy.