As noted above, there have been some reports of JPH2 downregulation in failing myocytes from a thoracic-aortic banding induced pressure-overload rat model (Wei et al., 2010), transgenic mouse models of hypertrophic or dilated cardiomyopathies (Minamisawa et al., 2004), and human hypertrophic cardiomyopathy (Landstrom et al., 2007), dilated cardiomyopathy and ischemic cardiomyopathy (Zhang et al., 2013; Guo et al., 2015). The gene discussed is JPH2; the disease is dilated cardiomyopathy.