ZFHX3 and atrial fibrillation: Among them, the ZFHX3 gene is the second most highly associated with AF and affects inflammation, fibrosis, matrix deposition, and atrial structural changes (Nojiri et al., 2004; Park et al., 2013; Liu et al., 2014; Tomomori et al., 2018; Alí et al., 2019).