During 49.9 ± 40.3 months of follow-up, the existence of extra-PV triggers and LA remodeling were independently associated with a clinical recurrence of AF after AFCA but not with the ZFHX3. Finding suggested that ZFHX3 SNPs were associated with the extra-PV trigger, but not AF recurrence after AFCA. This evidence concerns the gene ZFHX3 and atrial fibrillation.