Zinc Deficiency Activates Ca2+ Leak From Endoplasmic Reticulum via Ryanodine Receptor 2 and p-CaMKII Is Involved in Zinc Deficiency-Induced Signal Transducer and Activator of Transcription 3 Activation. The gene discussed is CAMK2G; the disease is hyperinsulinemic hypoglycemia, familial, 4.