Multiple ZIP family members, such as ZIP1, ZIP2, ZIP7, ZIP10, ZIP13, and ZIP14, were reported to response to zinc deficiency, with the mRNAs of these ZIPs accumulate when cells are exposed to zinc chelator TPEN (Cousins et al., 2003; Dietrich et al., 2017; Du et al., 2019; Thokala et al., 2019). The gene discussed is SLC39A14; the disease is Zinc deficiency.