Hwang et al. reported that in the presence of sodium iodate (that induces oxidative stress), primary human H-RPE and ARPE-19 cells cultured in vitro increased PTX3 expression, and the newly synthesized protein impaired the transcription of antioxidant enzymes, while inducing that of AMD-associated genes (Hwang et al., 2019). The gene discussed is PTX3; the disease is age-related macular degeneration.