In this regard, PTX3 is a well-known ligand of complement factor H (CFH) (Deban et al., 2008), and genetic variations in the CFH gene, particularly the Y402H polymorphism in the complement control protein (CCP) module seven of the protein, are strongly associated with the risk of developing AMD, as anticipated above (Parente et al., 2017). Here, PTX3 is linked to age-related macular degeneration.