AMD and DR share cellular and molecular components of major inflammatory pathways, including the long pentraxin 3 (PTX3), long-known as a key mediator of vascular (Presta et al., 2018; Ristagno et al., 2019) and complement-dependent (Doni et al., 2019; Haapasalo and Meri, 2019) inflammation, and recently emerging as a novel player in retinal neurodegeneration (Wang et al., 2016; Stravalaci et al., 2020). The gene discussed is PTX3; the disease is age-related macular degeneration.