Initial evidence of an involvement of PTX3 in the pathogenesis of AMD dates back to 2008, when Yamada et al. documented the presence of this protein in the macula of an 81-year-old male with early AMD by means of immunohistochemistry on post-mortem human eye specimens (Yamada et al., 2008). This evidence concerns the gene PTX3 and age-related macular degeneration.