TNFRSF4 and systemic lupus erythematosus: While, treatment with antagonistic Ox40 mAb accelerated autoAb and LN, administration of an agonistic Ox40:Fc fusion protein in an IFNα-accelerated lupus model significantly delayed the onset of severe proteinuria and improved the survival, suggesting a benefit of targeting this pathway (Sitrin et al., 2017).