Kang et al. (2005) showed that a very low-dose of nucleosomal histone peptide efficiently controlled lupus in SNF1 lupus prone mice and induced Treg-subsets. The role of microbiome and probiotics in immune-regulation of SLE is also being actively researched. It was found that certain Clostridium strains reduced TH17 cells and induced Tregs. Further, Bifidobacterium bifidum supplementation prevented CD4 T-cell overactivation to restore Treg/Th17/Th1 imbalance in SLE via expanding Foxp3+IL-17+ populations, however, its effect on LN is still pending (López et al., 2016). This evidence concerns the gene CD4 and systemic lupus erythematosus.