Finally, we used inhibitors of Vascular Endothelial Growth Factor Receptor (VEGFR), Epidermal Growth Factor Receptor (EGFR), and Platelet-Derived Growth Factor Receptor (PDGFR) to detect whether the activation of the p38 signaling pathway by PFD was associated with angiogenesis-related VEGFR, EGFR, and PDGFR. The gene discussed is PDGFRB; the disease is polyostotic fibrous dysplasia.