Similarly, treatment with b-AP15 also stimulates the cytotoxic response of HCC cells by inhibiting the Notch1 (Figure 6) and Wnt/β-catenin signaling pathways and enhancing endoplasmic reticulum (ER) stress/unfolded protein response (UPR), thus increasing the apoptosis of HCC cells (Ding et al., 2018). This evidence concerns the gene NOTCH1 and hepatocellular carcinoma.