Moreover, pharmacological inhibition of MM cells using the nonselective USP14 inhibitor b-AP15 induced the downregulation of cyclin B1 as well as caspase-dependent apoptosis in human MM xenograft models, preventing tumor growth and prolonging survival (Table 2) (D'Arcy et al., 2011; D'Arcy and Linder, 2012; Tian et al., 2014). The gene discussed is USP14; the disease is Miyoshi myopathy.