The accumulation of intracellular protein aggregates, such as tau in Alzheimer’s disease (AD), α-synuclein in Parkinson’s disease (PD), and TAR DNA-binding protein 43 (TDP-43) in amyotrophic lateral sclerosis (ALS) is the main pathological hallmark of several neurodegenerative diseases (Ross and Poirier, 2004; Uversky, 2007; Andersen and Al-Chalabi, 2011; Ciechanover and Kwon, 2015). The gene discussed is MAPT; the disease is amyotrophic lateral sclerosis.