Liu et al. found that USP14 modulated the cell cycle progression of breast cancer cells by deubiquitinating cyclin B1, a critical regulator of the mitotic phase (M phase) (Yu et al., 2002; Porter and Donoghue, 2003; Ding et al., 2014; Liu et al., 2019). This evidence concerns the gene CCNB1 and breast carcinoma.