Emerging evidence demonstrates that RIP1-RIP3-MLKL-mediated necroinflammation is involved in the pathogenesis of obstructive nephropathy (Imamura et al., 2018; Popper et al., 2019), acute kidney injury (AKI) (Mulay et al., 2019), and the progression of AKI to CKD (Chen et al., 2018). This evidence concerns the gene MLKL and acute kidney injury.