In our model of UUO, the pathogenesis of renal fibrosis involves a complex network orchestrated by necroptosis, oxidative stress, inflammation, TGF-β1, and activation of Wnt/catenin signaling (Jiang et al., 2015; Dai et al., 2020; Jin et al., 2020). The gene discussed is TGFB1; the disease is renal fibrosis.