NR1H3 and metabolic disease: Lucidone (111), a natural occurring terpene derivative present in a folk medicine Lindera erythrocarpa Makino, has been found to inhibit adipogenesis in 3T3-L1 cells by decreasing adipogenic genes transcription levels, including LXRα, indicating that it is a nutraceutical to guard against obesity and subsequent metabolic disorders (Hsieh and Wang 2013; Wong et al., 2014).