Intriguingly, PA (142) and GPA (143) have been considered as antirenal cell carcinoma (RCC) drug candidates, whereas on account of LXRα, PA/GPA caused specific hepatotoxicity in RCC xenograft mice-induced ALT to 2.6- and 2.3-fold, as well as the AST to 1.6- and 2.2-fold higher than that of the control group, respectively. Here, NR1H3 is linked to renal cell carcinoma.