In the results, 156, 157, and 114 activated FXR along with potential impact in diabetes (Genet et al., 2010), and 157 also generated frail FXR agonism, along with moderate PXR agonism, which protected against LCA-induced hepatotoxicity and cholestasis (Chen Z. et al., 2014). Here, NR1H4 is linked to cholestasis.