Maninsigins A (257), isolated from Magnolia officinalis as a TCM for the therapy of asthma, dyspepsia, and asthmatic cough, suppressed FXR activation induced by CDCA with an IC50 value of 55.6 μM as an FXR antagonist (Shang et al., 2013). Here, NR1H4 is linked to dyspepsia.