Fucosterol (76), a steroid widespread in marine algae, could promote the transactivation of both LXRα (+155% at 200 μM) and LXRβ (+83% at 200 μM) serving as an LXRα/β dual agonist, further indicating nutritional implications in hypercholesterolemia and atherosclerosis (Hoang et al., 2012a). Here, NR1H3 is linked to familial hypercholesterolemia.