NFKB1 and lung carcinoma: However, in lung cancer cells (H441) CLEFMA inhibited the degradation of phosphorylated IκBα via proteasome inhibitors thus NF-κB was inhibited from translocating to the nucleus for expression, further induced cell apoptosis (Traenckner et al., 1994; McDade et al., 1999; Lagisetty et al., 2010).