Kasinski et al. (2008) confirmed that synthetic and natural chalcones can inhibit tumor by inhibiting NF-κB activation (Kasinski et al., 2008). However, CLEFMA did not show such a reduction in NF-κB expression levels in normal lung cancer cells (CCL151) (Lagisetty et al., 2010). Here, NFKB1 is linked to neoplasm.