NFKB1 and lung cancer: In addition, another function of NF-κB is to regulate the expression of cyclin D which performs the phase transition from G1 to S in the cell cycle, CLEFMA treatment on lung cancer cells H441 suppress NF-κB, which further leading to reduced expression of cyclin D resulting in the arrest of phase S of H441 cells (Lagisetty et al., 2010).