Piperine treatment resulted in increased phosphorylation of JNK and p38 MAPK in ovarian cancer cells, which induced apoptosis in A2780 cells suggesting that the intrinsic apoptotic pathway mediated by JNK/p38 MAPK can be induced in ovarian cancer cells by piperine treatment (Si et al., 2018). This evidence concerns the gene MAPK8 and ovarian cancer.