Recent observation on the anticancer activity of piperine and piperidine has described its mechanism of activating signaling pathways like NF-κB, PI3k/Aκt etc. which are involved in cancer progression including caspase-dependent pathway to induce apoptosis (Rather and Bhagal, 2018; Zadorozhna et al., 2019). This evidence concerns the gene AKT1 and cancer.