Among the TOP30 genes identified by FGLGNSCCA, genes such as ZFX (Soleimani et al., 2020), XIST (Wang et al., 2018), E2F5 (Johanson et al., 2008), KDM6A (Davis et al., 2020), TXLNG (Hotokezaka et al., 2015), and PTPRK (Chen et al., 2018) have been confirmed to play an eventful role in the AD process or participation in related biological processes. The gene discussed is E2F5; the disease is Alzheimer disease.