SNAP25 and Alzheimer disease: Indeed, optimal levels of SNAP-25 are important for neurotransmission, and changes in SNAP-25 expression may contribute to the pathophysiology of various diseases, including Alzheimer's disease, schizophrenia, autism, and ADHD (Kim et al., 2007; Najera et al., 2019; Tang, 2021; Wang et al., 2021).