More recently, Dzhala and Staley (2021) have identified in an organotypic hippocampal slice model that the KCC2 antagonist VU0463271, by decreasing Cl− extrusion from the intracellular compartment, increases its intracellular elevations during ictal events and discloses a pattern of continuous interictal-like discharges resembling status epilepticus. The gene discussed is SLC12A5; the disease is status epilepticus.