Consistent with evidence for changes to the pre- and post-synaptic machinery for GABAergic signaling in FXS, both the frequency and amplitude of spontaneous and miniature inhibitory post-synaptic potentials (sIPSCs, mIPSCs) are reduced in the amygdala of adult (Olmos-Serrano et al., 2010) and juvenile (Vislay et al., 2013) FMR1 KO mice. This evidence concerns the gene FMR1 and fragile X syndrome.