Acute treatment of FMR1 KO mice with gaboxadol, a GABAA receptor agonist selective for extrasynaptic receptors mediating tonic currents, rescues hyperexcitability of amygdala principal neurons and rescued certain behavioral phenotypes in FMR1 KO mice, suggesting reduced tonic GABAergic inhibition in the amygdala contributes to hyperexcitability phenotypes in FXS (Olmos-Serrano et al., 2010, 2011). Here, FMR1 is linked to fragile X syndrome.