DNMT3A1 is controlled by activated NMDAR and the expression of NMDAR is also mediated by epigenomics. In epilepsy, GRIN2B DNA methylation levels were increased and BDNF DNA methylation levels were decreased, which leading to decreased mRNA and protein expression of GluN2B and increased mRNA and protein expression of BDNF. Suppressive DNMT can increase excitatory postsynaptic potential in hippocampal slices of epileptic rats. Increased TBR1 expression in AF9 mutants is associated with increased expression of GluN1 subunit which is regulated by TBR1. This evidence concerns the gene DNMT1 and epilepsy.