GluN1 subunit, the essential subunit of functional NMDAR is encoded by GRIN1, and GRIN1 mutations have a significant effect on neuronal activity, causing various types of epilepsy, including SE, focal dyscognitive seizures, myoclonic seizures, febrile seizures, spasms, hypermotor seizures, tonic and atonic seizures, generalized seizures, etc (Wyllie et al., 2013; Fry et al., 2018). This evidence concerns the gene GRIN1 and Generalized-onset seizure.