A rare variant of GRIN2A associated with epilepsy disrupts CaMKIIα phosphorylation of GluN2A and NMDAR trafficking, which demonstrates a role of GluN2A for CaMKIIα phosphorylation in receptor targeting and suggests that the defects of NMDAR trafficking are related to epilepsy (Mota Vieira et al., 2020). Here, GRIN2A is linked to epilepsy.