Deletion or mutations of LIS1 (Lissencephaly 1 protein; encoded by PAFAH1B1, Platelet activating factor acetylhydrolase 1b regulatory subunit 1) are the major cause of classical lissencephaly in humans (Reiner et al., 1993; Romero et al., 2018). Here, PAFAH1B1 is linked to lissencephaly spectrum disorders.