NDE1 and lissencephaly spectrum disorders: NDE1 (nudE neurodevelopment protein 1), whose mutations in human patients can lead to a severe microcephaly with lissencephaly, is involved in centrosome duplication and mitotic spindle assembly, attachment of microtubules to kinetochores and proper neuronal migration (Feng and Walsh, 2004; Vergnolle and Taylor, 2007; Alkuraya et al., 2011).