While TSPO PET imaging has already made it possible to longitudinally follow the neuroinflammatory process in Tg mice models of AD (Sérrière et al., 2015; Takkinen et al., 2017; Chaney et al., 2018), the present study demonstrates for the first time that such an in vivo method is suitable for evaluating long-term treatment effects. This evidence concerns the gene TSPO and Alzheimer disease.