Increasing evidence has demonstrated that both astrocytes and tumor cells express purinergic receptors and purine-metabolizing enzymes, which can trigger a set of biological effects in the CNS (Wink et al., 2003, 2006; Rodrigues et al., 2015; Azambuja et al., 2019a; Illes et al., 2019; Campos-Contreras et al., 2020). The gene discussed is P2RY1; the disease is neoplasm.