In addition, PBX3 was found to mediate the effects of several miRNAs, such as miR‐144, miR‐495 and miR‐98, on invasion and metastasis in cancer.53, 92, 93 The molecular mechanisms involved in invasion and metastasis are very complicated and have not been fully understood; however, these findings strongly suggest that PBXs are effective targets for preventing cancer invasion and metastasis as well as cancer progression. Here, PBX3 is linked to cancer.