The polyneuropathy and protein misfolding disorder, hereditary transthyretin-mediated amyloidosis (hTTR) is caused by the abnormal breakdown of the transthyretin (TTR) protein which deposits as amyloid fibrils in various organs and tissues including frequently in the peripheral nervous system, the deposits ultimately lead to organ failure and death within five to 15 years of disease onset [90]. The gene discussed is TTR; the disease is polyneuropathy.