From the value of the area under curve (AUC), SPP1 has significant prediction power for tumor immunotherapy (AUC: 0.700 in GSE111636; AUC: 0.596 in RCC; AUC: 0.964 in GSE67501; AUC: 0.700 in GSE26383; AUC: 0.625 in GSE79691; AUC: 0.687 in GSE100797) (Figure 6(m-r)). The gene discussed is SPP1; the disease is neoplasm.