In addition, according to the Kaplan-Meier and COX survival analyses, we found that high expression of SPP1 in most cancers is indicative of a poor prognosis, such as in CESC, ESCA, GBM, LGG, LIHC, LUAD, MESO, PAAD, PRAD, and STAD. The gene discussed is SPP1; the disease is cancer.