We found that SPP1 mRNA expression was significantly higher in BLCA, BRCA, CESC, CHOL, COAD, ESCA, GBM, HNSC, KIRP, LIHC, LUAD, LUSC, PRAD, READ, STAD, THCA, and UCEC tumor tissues compared with that in normal tissues, indicating that it might play an oncogenic role in the development of most tumors. This evidence concerns the gene SPP1 and neoplasm.