SPP1 and cancer: The Kaplan-Meier analysis indicated that the high SPP1 expression significantly decreased OS in six cancers: CESC (p = 0.022), GBM (p = 0.050), LGG (P < 0.001), LIHC (P < 0.001), LUAD (p = 0.035), and PAAD (p = 0.042) (Figure 2(a-f)).