Type II diabetes mellitus is one type of DM found in more than 90% of cases of DM and could be attributed to obesity, overweight and lack of physical activity, marked by pancreatic insulin release, when the body has not been trained to utilise insulin developed for glucose transfer, and the emergence of insulin resistance contributes to an increase of blood glucose or hyperglycaemia.88 Here, INS is linked to obesity due to melanocortin 4 receptor deficiency.