Recent studies have reported that integrin β like 1 protein (ITGBL1), which is also called the ten beta integrin EGF-like repeat domain, regulated various forms of cancer cell migration, invasion and metastasis through the WNT/PCP, FAK/SRC, and TGF-β signaling pathways (Berg et al. 1999; Gan et al. 2016; Li et al. 2015; Sun et al. 2016). The gene discussed is PTK2; the disease is cancer.