Takahashi-Kanemitsu et al. [124] revealed that the non-physiological scaffolding actions of CagA granted cells numerous phenotypic tumor markers and intensified the malignant conversion, namely continuing proliferation, invasion, growth suppressors elusion, etc. In addition, under chronic inflammation, the tumorigenic activity of CagA was further reinforced [125]. Here, S100A8 is linked to neoplasm.