A study by Wang et al. [165] indicated that HMGB1 partially participated in the promotion of GC cell proliferation and the potential of metastasis induced by intensive human antigen R. A study by Tian et al. [159] reported the suppression of stomach cancer cell proliferation and colony formation, and the induction of apoptosis following HMGB1-knockdown. The gene discussed is HMGB1; the disease is gastric neoplasm.