Chung et al. [166] conducted a series of analyses on 27 GC patients (10 EGC, 10 advanced GC-M0 and 7 advanced GC-M1), as well as GC cells, and reported that the enhanced expression of HMGB1 promoted angiogenesis through the mediation of IL-8. The gene discussed is HMGB1; the disease is gastric cancer.