Furthermore, there was a connection between APOE ε2 and an increased risk of intestinal and diffuse histotypes of GC; completely different conditions were obtained with regards to the association between APOE ε2 and tumor node classification or stage of GC patients, with APOE polymorphic alleles found to be linked to a developmental risk of GC and irrelevant to its progression. The gene discussed is APOE; the disease is neoplasm.