6-month-old APP/PS1 AD model has previously been shown to exhibit increased wakefulness during the 12 h light phase (Zhang et al. 2019a; Zhurakovskaya et al. 2019); some other studies have reported that 9-month-old APP/PS1 female mice displayed reduced REM and NREM sleep stages across both light and dark phases (Roh et al. 2012); reduced NREM and increased wakefulness during 12 h light phase also has been observed in PLB1 Triple (Platt et al. 2011). This evidence concerns the gene PSEN1 and Alzheimer disease.