Mechanistically, the authors (86) showed that activated CD8 T cells released the effector cytokine, interferon gamma (IFNγ), which upon binding to cancer cells triggered the downregulation of SLC7A11 expression, thereby impairing cystine uptake and resulting in lipid peroxidation and tumor ferroptosis (86) (Fig. 4B). This evidence concerns the gene CD8A and neoplasm.