PLIN5 and Insulin resistance: From the numerous studies (more than 60) where PLIN5 was overexpressed or deleted/downregulated in cells or in mice, more than 25 studies directly or indirectly demonstrate that the deletion or downregulation of PLIN5 causes cellular stress and/or mitochondrial dysfunction linked to increased (and likely uncontrolled) FA oxidation, lipotoxicity, and/or insulin resistance (11, 12, 38, 39, 40, 41).