CD79A and Rotavirus infection: The first line of protection from rotavirus infection is provided by secretory IgA on the gut mucosa; therefore, it is likely that serum anti-rotavirus IgA underestimates the level of protection provided by a rotavirus vaccine.16, 17 This presents an additional challenge for the assessment of the immune response after a birth dose of a rotavirus vaccine, as IgA does not cross the placenta and serum IgA responses might not be as reliable in the first weeks of life.18