Strong synergism was also found when combining talazoparib with the novel SAHA-bendamustine hybrid, NL101, in AML, both in vitro (MV4-11; HL-60; RUNX1-RUNX1T1 rearranged AML cell line, KASUMI1) and in the xenograft model (MV4-11 cells). Here, RUNX1 is linked to acute myeloid leukemia.