However, it was shown to potentiate the efficacy of the alkylating agent temozolomide (TMZ) in different ALL and AML cell lines and, in particular, in mismatch repair (MMR)-deficient ALL (T-ALL: MOLT4 and HBS2; REH) cell lines with low O6-methylguanine-DNA methyltransferase (MGMT) activity. This evidence concerns the gene MGMT and acute lymphoblastic leukemia.