In addition, PARPi were reported to sensitize AML cell lines and primary cells to human tumor necrosis factor- α-related apoptosis-inducing ligand (TRAIL), a key effector molecule of NK cells, by activating the expression of FAS and TNFRSF10B proteins through enhanced the binding of the transcription factor Sp1 to the promoter) [102]. The gene discussed is FAS; the disease is acute myeloid leukemia.