The efficacy of the triple combination was confirmed also on primary leukemic cells (de novo AML, secondary AML, T cell prolymphocytic leukemia and Mixed phenotypes ALL) in which the combination induced DNA damages (H2AX marker) and triggered apoptosis (cleaved PARP1 and Caspase 9) [112]. The gene discussed is PARP1; the disease is acute myeloid leukemia.