Inactivation of the NF-κB pathway through IKKβ inhibition and olaparib potentiated the efficacy of danunorubin in AML cells (RUNX1-RUNX1T1 rearranged AML cell line, KASUMI1; erythroleukemia cell line, KG1a) and xenograft models (mice transplanted with KG1a cells), both in monotherapy and when used in combination, by increasing apoptosis and reducing cell proliferation [105]. This evidence concerns the gene NFKB1 and acute myeloid leukemia.