These data open a new scenario for a rationale usage of PARPi in AML in order to maximize the patients’ benefit, including conditions of functional immune response, like minimal residual disease, or in combination with immunotherapies, as immune checkpoint inhibitors, allogeneic stem cell transplantation, NK cell infusion, recombinant TRAIL, small molecules or monoclonal antibodies functioning as receptor agonists that are currently under investigation. The gene discussed is TNFSF10; the disease is acute myeloid leukemia.