AFF1 and acute myeloid leukemia: Moreover, olaparib caused synthetic lethality in combination with decitabine in AML models (KG1a; APL cell line, HL-60; KMT2A-AFF1 rearranged AML cell line, MV4-11; FLT3-ITD AML cell line, PL21) by disrupting BER, which was required for repairing decitabine-induced DNA lesions through recruitment of XRCC1 at DNMT1 foci and repair of trapped DNMT1 [106].