PARP1 and acute myeloid leukemia: According to public genomic data available on acute leukemias on the cBio portal [64] (TCGA-LAML [65] and Beat AML [66] datasets) and our cohort (NGS-PTL [67, 68]), there is no evidence of genomic alterations of PARP1 in adult patients and few cases have been reported in pediatric cohorts [64] (2/295 in TARGET-AML [69], 0.7%; 8/819 in TARGET-ALL [70], 1.0%, Fig. 3A and Table 2).