Disturbances in the regulation of hepcidin are involved in the pathogenesis of several kinds of iron-related disorders, such as iron overload in hereditary hemochromatosis (HH) and nontransfused β-thalassemia; meanwhile, the overproduction of hepcidin is associated with the development of iron-restricted anemia, which is observed in patients with chronic kidney disease, chronic inflammatory diseases, some cancers, and inherited iron-refractory iron deficiency anemia [7]. Here, HAMP is linked to chronic kidney disease.