The role of hyperresponsive TLR7-signaling as one reason for the development of these autoantibodies in SLE patients is known in the field, and thus the appearance of these autoantibodies in patients suffering from severe COVID-19 disease implies overactive TLR7-signaling at a later stage, when the disease has progressed to a severe form. The gene discussed is TLR7; the disease is systemic lupus erythematosus.