At a first glance, the dependence on strong signaling via the TLR7-pathway in the early phase of infection with SARS-CoV-2 might be seen as surprising, since there are two major pathways for the activation of an antiviral type I IFN response to infection with RNA viruses: RIG-I-like receptors (RLRs) and the Toll-like receptors (TLRs), respectively [23]. The gene discussed is TLR7; the disease is infection.