Based on unconditional binary Logistic regression analysis, MGP (OR: 1.021, 95%CI: 0.062-1.334, P<0.001) and Fetuin-A (OR: 0.209, 95%CI: 0.101-0.442, P<0.001) were both protective factors for degenerative calcified aortic valve disease, while the adverse effect of Lp(a) (OR: 5.798, 95%CI: 3.001-8.678, P=0.003) (Table 3). Here, MGP is linked to aortic valve disorder.