B4GALNT1 and Parkinson disease: Specifically, Wu and coworkers demonstrated that the disruption of B4galnt1 gene in mice determines the development of typical PD features both in central and in peripheral tissues: motor impairment, loss of dopaminergic neurons from SN, αS aggregation, alterations of gastrointestinal, sympathetic cardiac, and cerebral cognitive systems [56, 57, 59, 60].