To investigate the effect of Tbk1 loss in the presence of other ALS‐related genes, mouse models of ALS have been generated on the Tbk1+/– background, like Tg‐TDP‐43G298STbk1+/–, that developed more severe pathology although life expectancy was not significantly altered.163. Here, TBK1 is linked to amyotrophic lateral sclerosis.