Despite the fact that symptoms developed earlier in Tg‐SOD1G93ATbk1+/– than in Tg‐SOD1G93A, the Tg‐SOD1G93ATbk1+/– had longer life expectancy, which may indicate differential effects of Tbk1 in early and late stages of ALS.164. This evidence concerns the gene TBK1 and amyotrophic lateral sclerosis.