Consistent with our findings, Li et al. recently demonstrated that silencing Smad4 in KPC pancreatic tumor cells accelerated T cell infiltration and suppressed implantation tumor growth.[16a] Interestingly, when studying the epigenetic mechanism responsible for PDAC tumor progression, Hou et al. also observed striking tumor growth inhibition when Smad4 expression was silenced in mouse pancreatic tumor cells with a KrasG12Dp53−/− background.[39]. Here, SMAD4 is linked to neoplasm.