SMAD4 and neoplasm: One recent study identified a four‐chemokine signature to predict PDAC immune infiltration and prognosis, indicating that T cell infiltration and antitumor immunity in human pancreatic cancers may require additional signals such as chemokines besides tumor immunogenicity.[54] Interestingly, in line with different DC infiltration status found in SMAD4 WT versus mutant PDAC cases in our CIBERSORT analysis, the authors also found that the chemokine signature was associated with STING expression and cDC1 marker expression.