Consistently, cDC1 was found essential for T cell infiltration in PDAC tumors in another study characterizing the heterogeneity of the PDAC tumor microenvironment.[50] Both tumor cell‐derived or host‐derived IFN‐I signaling contributes to antitumor immunity in vivo.[51] Interestingly, DC‐specific Sting deficiency has no impact on WT or Smad4KO PDAC tumor growth, suggesting that tumor‐intrinsic STING/IFN‐I signaling, but not STING in DCs, is critical for Smad4KO‐mediated tumor inhibition. The gene discussed is MPPE1; the disease is neoplasm.