A recent study reported that autophagy in PDAC cells could induce MHC‐I degradation to promote tumor immune evasion, and blockade of autophagy in PDAC tumor cells restored surface level of MHC‐I and improved antigen presentation, leading to enhanced antitumor immunity in syngeneic host mice.[28] Here, we examined the microtubule‐associated protein light chain 3beta (LC3B) protein level as a marker for autophagy level, [29] and found that Smad4KO cells had higher levels of LC3B expression than WT cells (Figure S4A, Supporting Information). Here, MAP1LC3B is linked to neoplasm.