The lack of clinical remission may attribute to not only inappropriate distinguish but also a complication with essential hypertension or chronic kidney disease or subclinical hypercortisolism,40 long duration of hypertension, as well as male sex, elderly patients, KCNJ5 mutation carriers,41 etc. Proye and coworkers reported that the prevalence of hypertension was almost the same in postoperative patients as the prevalence of essential hypertension in a random population of the same age.42 The gene discussed is KCNJ5; the disease is adrenal gland hyperfunction.