Multivariate logistic regression model was applied to further analyze the independent factors for clinical response at W12 in RA patients, which indicated that higher ITIH4 at W12 (p = 0.001) and higher CRP (p = 0.005) were independent factors for clinical response at W12 in RA patients (Supplementary table S1). The gene discussed is CRP; the disease is rheumatoid arthritis.