The inflammation‐regulating role of ITIH4 is conflicting; although some studies showed that ITIH4 served as a pro‐inflammatory cytokine, several evidence has disclosed the anti‐inflammatory properties of ITIH4 in COPD, inflammatory bowel disease, etc.24, 39, 40, 41For instance, one previous study finds that ITIH4 is negatively related to IL‐6 in bronchoalveolar lavage fluid of COPD patients.39 The gene discussed is IL6; the disease is inflammatory bowel disease.