CALR and cancer: Photothermal treatment can induce cancer cells to immunogenic cell death (ICD), which is typically released calreticulin (CRT), high mobility group box 1 (HMGB1) and ATP to extracellular, thereby recruiting immune cells.[20, 21, 22] However, ATP turns into adenosine by CD39 and CD73 ectoenzymes participation, which binds to the A2A receptor (A2AR) of immune cells to suppress their activity.