It is worth mentioning that although it is advocated to monitor maternal thyroid hormone level during pregnancy, the risk of current clinical guidelines treatment on mothers is definitely there, that slightly overtreatment of maternal hypothyroidism may lead to fetal developmental disorders.[40] Moreover, it remains unclear if the high incidence of thyroid diseases in children and adolescents is associated with fetal thyroid dysplasia. The gene discussed is TG; the disease is thyroid gland disorder.