These include PAX8, NKX2‐1, FOXE1, NKX2‐5, JAG1, and GLIS3 genes.[39] We suppose the thyroid organoid, derived from first trimester tissues, may help to establish a congenital hypothyroidism model by gene manipulation, and this may facilitate further understanding of thyroid development and the study of congenital thyroid disorders. Here, GLIS3 is linked to congenital hypothyroidism.