Another study discovers that miR‐126 deficiency upregulates sprouty‐related EVH1 domain‐containing protein 1 (SPRED‐1) to reduce the activation of RAF kinase and mitogen‐activated protein kinase, thereby inhibits the vascular endothelial growth factor pathway, and subsequently aggravates pulmonary hypertension with right ventricular failure.26 This evidence concerns the gene SPRED1 and pulmonary hypertension.