Another study discovers that miR‐126 deficiency upregulates sprouty‐related EVH1 domain‐containing protein 1 (SPRED‐1) to reduce the activation of RAF kinase and mitogen‐activated protein kinase, thereby inhibits the vascular endothelial growth factor pathway, and subsequently aggravates pulmonary hypertension with right ventricular failure.26 The gene discussed is SPRED1; the disease is pulmonary arterial hypertension.