This may be due to the fact that miR‐126 can promote the release of inflammatory cytokines by regulating multiple genes (such as IL‐13) and signaling pathways (such as TLR4 signaling pathway), thus aggravating the inflammatory response and further increasing the risk of COPD and its acute exacerbation.12, 27, 28. This evidence concerns the gene TLR4 and chronic obstructive pulmonary disease.