Typical control subjects exhibited normal hnRNP K localisation with strong nuclear staining intensity and weaker cytoplasmic staining (Figure 1A), while FTLD/AD subjects typically exhibited an abnormal pattern of staining within these neurons consisting of hnRNP K nuclear depletion and granular cytoplasmic accumulation of the protein (Figure 1B,C). Here, HNRNPK is linked to Alzheimer disease.