The Cox proportional hazard analysis revealed that DOAC therapy was independently associated with lower mortality after adjustments for age, diabetes mellitus, and albumin level (HR, 0.55; 95% CI 0.30–0.99; p = 0.045) in the eGFR < 45 mL/min/1.73 m2 subgroup (Table 4) but not associated in the eGFR ≥ 45 mL/min/1.73 m2 subgroup (HR, 1.27; 95% CI 0.60–2.67; p = 0.533). This evidence concerns the gene ALB and diabetes mellitus.