A previous study using a mouse model of HCC and cholangiocellular carcinoma (CCC) induced by the overexpression of v-Akt and N-Ras oncogenes in hepatocytes reported the different effects of the blockade of Notch1, Notch2, and Notch3 signaling on the tumor progression32. The gene discussed is NOTCH2; the disease is cholangiocarcinoma.